Neighbourhood continuity is not required for correct testis gene expression in Drosophila.

ABSTRACT: It is now widely accepted that gene organisation in eukaryotic genomes is non-random and it is proposed that such organisation may be important for gene expression and genome evolution. In particular, the results of several large-scale gene expression analyses in a range of organisms from yeast to human indicate that sets of genes with similar tissue-specific or temporal expression profiles are clustered within the genome in gene expression neighbourhoods. While the existence of neighbourhoods is clearly established, the underlying reason for this facet of genome organisation is currently unclear and there is little experimental evidence that addresses the genomic requisites for neighbourhood organisation. We report the targeted disruption of three well-defined male-specific gene expressio

SUBMITTER: Meadows LA 

PROVIDER: S-EPMC2994658 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature