Polyamines are present in mast cell secretory granules and are important for granule homeostasis.

ABSTRACT:

Background

Mast cell secretory granules accommodate a large number of components, many of which interact with highly sulfated serglycin proteoglycan (PG) present within the granules. Polyamines (putrescine, spermidine and spermine) are absolutely required for the survival of the vast majority of living cells. Given the reported ability of polyamines to interact with PGs, we investigated the possibility that polyamines may be components of mast cell secretory granules.

Methodology/principal findings

Spermidine was released by mouse bone marrow derived mast cells (BMMCs) after degranulation induced by IgE/anti-IgE or calcium ionophore A23187. Additionally, both spermidine and spermine were detected in isolated mouse mast cell granules. Further, depletion of polyamines by cultu

SUBMITTER: Garcia-Faroldi G 

PROVIDER: S-EPMC2994821 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature