Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.

ABSTRACT:

Background

The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species. These factors could represent a constellation of heritable characteristics that promote transformation events and/or facilitate the establishment of a microenvironment that is conducive for survival of malignant blood vessel-forming cells. The hypothesis for this study was that characteristic molecular features distinguish hemangiosarcoma from non-malignant endothelial cells, and that such features are informative for the etiology of this disease.

Methods

We first investigated mutations of VHL and Ras family genes that might drive hemangiosarcoma by sequencing tumor DNA and mRNA (cDNA). Protein expressi

SUBMITTER: Tamburini BA 

PROVIDER: S-EPMC2994824 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature