Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases.

ABSTRACT:

Background

The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes. Whether they are associated with emphysema is not known.

Methods

Twelve previously reported single nucleotide polymorphisms (SNPs) in SERPINA1 (rs8004738, rs17751769, rs709932, rs11832, rs1303, rs28929474, and rs17580), SERPINA3 (rs4934, rs17473, and rs1800463), and SERPINE2 (rs840088 and rs975278) were genotyped in samples obtained from 1,335 consecutive autopsies of elderly Japanese people. The association between these SNPs and the severity of emphysema, as assessed using macroscopic scores, was determined.

Results

Emphysema of more than moderate degree was detected

SUBMITTER: Fujimoto K 

PROVIDER: S-EPMC2994839 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature