Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort.

ABSTRACT:

Background

Cofactors might affect the risk of the rare progression from infection with carcinogenic human papillomavirus (HPV) to cervical premalignancy to invasive cancer. Some studies have observed that Chlamydia trachomatis infection is associated with increased risk for cervical cancer. In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV.

Methods

We identified 182 women with prevalent and 132 women with incident histological cervical intraepithelial neoplasia grade 2 (CIN2), grade 3 (CIN3), or cervical cancer (CIN2+) in the Costa Rica HPV Natural History Study. Control subjects were 995 (approximately 10% of the 10 049) subjects who were randomly selected from the same study. Cervical HPV status

SUBMITTER: Safaeian M 

PROVIDER: S-EPMC2994864 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature