A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.

ABSTRACT:

Background

Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patients.

Methods/principal findings

MS subjects were genotyped for five single nucleotide polymorphisms (snps) associated with susceptibility to AD: PICALM, CR1, CLU, PCK1, and ZNF224. We assessed brain volume using Brain Parenchymal Fraction (BPF) measurements obtained from Magnetic Resonance Imaging (MRI) data and cognitive function using the Symbol Digit Modalities Test (SDMT). Genotypes were correlated with cross-sectional BPF and SDMT scores using linear regression after adjusting fo

SUBMITTER: Xia Z 

PROVIDER: S-EPMC2994939 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature