Ryanodine receptors selectively contribute to the formation of taste-evoked calcium signals in mouse taste cells.

ABSTRACT: The peripheral taste system uses multiple signaling pathways to transduce a stimulus into an output signal that activates afferent neurons. All of these signaling pathways depend on transient increases in intracellular calcium, but current understanding of these calcium signals is not well developed. Using molecular and physiological techniques, this study establishes that ryanodine receptors (RyRs), specifically isoform 1, are expressed in taste cells and that their physiological function differs among cell types employing different signaling pathways. RyR1 contributes to some taste-evoked signals that rely on calcium release from internal stores but can also supplement the calcium signal that is initiated by opening voltage-gated calcium channels. In taste cells expressing both signaling

SUBMITTER: Rebello MR 

PROVIDER: S-EPMC2994989 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature