Understanding the population structure of North American patients with cystic fibrosis.

ABSTRACT: It is generally presumed that the cystic fibrosis (CF) population is relatively homogeneous, and predominantly of European origin. The complex ethnic make-up observed in the CF patients collected by the North American CF Modifier Gene Consortium has brought this assumption into question, and suggested the potential for population substructure in the three CF study samples collected from North America. It is well appreciated that population substructure can result in spurious genetic associations. To understand the ethnic composition of the North American CF population, and to assess the need for population structure adjustment in genetic association studies with North American CF patients, genome-wide single-nucleotide polymorphisms on 3076 unrelated North American CF patients were used to

SUBMITTER: Li W 

PROVIDER: S-EPMC2995003 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature