Identifying functional miRNA-mRNA regulatory modules with correspondence latent dirichlet allocation.

ABSTRACT:

Motivation

MicroRNAs (miRNAs) are small non-coding RNAs that cause mRNA degradation and translational inhibition. They are important regulators of development and cellular homeostasis through their control of diverse processes. Recently, great efforts have been made to elucidate their regulatory mechanism, but the functions of most miRNAs and their precise regulatory mechanisms remain elusive. With more and more matched expression profiles of miRNAs and mRNAs having been made available, it is of great interest to utilize both expression profiles to discover the functional regulatory networks of miRNAs and their target mRNAs for potential biological processes that they may participate in.

Results

We present a probabilistic graphical model to discover functional miRNA regulato

SUBMITTER: Liu B 

PROVIDER: S-EPMC2995118 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature