ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis.

ABSTRACT:

Rationale

Antiatherogenic effects of plasma high-density lipoprotein (HDL) include the ability to inhibit apoptosis of macrophage foam cells. The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are upregulated during the phagocytosis of apoptotic cells (efferocytosis).

Objective

The goal of this study was to determine the roles of ABCA1 and ABCG1 in preserving the viability of macrophages during efferocytosis.

Methods and results

We show that despite similar clearance of apoptotic cells, peritoneal macrophages from Abca1(-/-)Abcg1(-/-), Abcg1(-/-), and, to a lesser extent, Abca1(-/-) mice are much more prone to apoptosis during efferocytosis compared to wild-type cel

SUBMITTER: Yvan-Charvet L 

PROVIDER: S-EPMC2995809 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature