Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation.

ABSTRACT:

Objective

Infiltrating immune cells play a central role in degenerative joint disease associated with osteoarthritis (OA) and particle-mediated periprosthetic osteolysis. The goal of this study was to characterize a newly identified population of synovial tissue-infiltrating natural killer (NK) cells obtained from patients with OA or patients with periprosthetic joint inflammation.

Methods

Synovial and interfacial tissue samples were collected from patients with OA who were undergoing primary or revision total joint replacement (TJR) surgery. The histologic features of OA synovium obtained from patients undergoing primary surgery and interfacial tissue obtained from patients undergoing revision surgery were determined by immunohistochemistry and immunofluorescence. Synovial

SUBMITTER: Huss RS 

PROVIDER: S-EPMC2995813 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature