Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells.

ABSTRACT: Tissue stem cells must be endowed with superior maintenance and repair systems to ensure genomic stability over multiple generations, which would be less necessary in more differentiated cells. We previously reported that human keratinocyte stem cells were more resistant to ionizing radiation toxicity than their direct progeny, the keratinocyte progenitor cells. In the present study we addressed the mechanisms underlying this difference. Investigations of DNA repair showed that both single and double DNA strand breaks were repaired more rapidly and more efficiently in stem cells than in progenitors. As cell signaling is a key regulatory step in the management of DNA damage, a gene profiling study was performed. Data revealed that several genes of the fibroblast growth factor type 2 (FGF2)

SUBMITTER: Harfouche G 

PROVIDER: S-EPMC2996082 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature