Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.

ABSTRACT: Within the healthy population, there is substantial, heritable, and interindividual variability in the platelet response. We explored whether a proportion of this variability could be accounted for by interindividual variation in gene expression. Through a correlative analysis of genome-wide platelet RNA expression data from 37 subjects representing the normal range of platelet responsiveness within a cohort of 500 subjects, we identified 63 genes in which transcript levels correlated with variation in the platelet response to adenosine diphosphate and/or the collagen-mimetic peptide, cross-linked collagen-related peptide. Many of these encode proteins with no reported function in platelets. An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative associa

SUBMITTER: Goodall AH 

PROVIDER: S-EPMC2996120 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature