Changes in resting neural connectivity during propofol sedation.

ABSTRACT:

Background

The default mode network consists of a set of functionally connected brain regions (posterior cingulate, medial prefrontal cortex and bilateral parietal cortex) maximally active in functional imaging studies under "no task" conditions. It has been argued that the posterior cingulate is important in consciousness/awareness, but previous investigations of resting interactions between the posterior cingulate cortex and other brain regions during sedation and anesthesia have produced inconsistent results.

Methodology/principal findings

We examined the connectivity of the posterior cingulate at different levels of consciousness. "No task" fMRI (BOLD) data were collected from healthy volunteers while awake and at low and moderate levels of sedation, induced by the anest

SUBMITTER: Stamatakis EA 

PROVIDER: S-EPMC2996305 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature