Merging transcriptomics and metabolomics--advances in breast cancer profiling.

ABSTRACT:

Background

Combining gene expression microarrays and high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS) of the same tissue samples enables comparison of the transcriptional and metabolic profiles of breast cancer. The aim of this study was to explore the potential of combining these two different types of information.

Methods

Breast cancer tissue from 46 patients was analyzed by HR MAS MRS followed by gene expression microarrays. Two strategies were used to combine the gene expression and metabolic data; first using multivariate analyses to identify different groups based on gene expression and metabolic data; second correlating levels of specific metabolites to transcripts to suggest new hypotheses of connections between metabolite levels and

SUBMITTER: Borgan E 

PROVIDER: S-EPMC2996395 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature