Foundational model of structural connectivity in the nervous system with a schema for wiring diagrams, connectome, and basic plan architecture.

ABSTRACT: The nervous system is a biological computer integrating the body's reflex and voluntary environmental interactions (behavior) with a relatively constant internal state (homeostasis)-- promoting survival of the individual and species. The wiring diagram of the nervous system's structural connectivity provides an obligatory foundational model for understanding functional localization at molecular, cellular, systems, and behavioral organization levels. This paper provides a high-level, downwardly extendible, conceptual framework--like a compass and map--for describing and exploring in neuroinformatics systems (such as our Brain Architecture Knowledge Management System) the structural architecture of the nervous system's basic wiring diagram. For this, the Foundational Model of Connectivity's

SUBMITTER: Swanson LW 

PROVIDER: S-EPMC2996420 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature