Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis.

ABSTRACT: One extra chromosome copy (i.e., trisomy) is the most common type of chromosome aberration in cancer cells. The mechanisms behind the generation of trisomies in tumor cells are largely unknown, although it has been suggested that dysfunction of the spindle assembly checkpoint (SAC) leads to an accumulation of trisomies through failure to correctly segregate sister chromatids in successive cell divisions. By using Wilms tumor as a model for cancers with trisomies, we now show that trisomic cells can form even in the presence of a functional SAC through tripolar cell divisions in which sister chromatid separation proceeds in a regular fashion, but cytokinesis failure nevertheless leads to an asymmetrical segregation of chromosomes into two daughter cells. A model for the generation of trisom

SUBMITTER: Gisselsson D 

PROVIDER: S-EPMC2996656 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature