Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.

ABSTRACT: A hallmark of diabetes is an absolute or relative reduction in the number of functional β cells. Therapies that could increase the number of endogenous β cells under diabetic conditions would be desirable. Prevalent gene targeting mouse models for assessing β-cell proliferation and diabetes pathogenesis only address whether deletion of a gene prevents the development of diabetes. Models testing whether acute excision of a single gene can ameliorate or reverse preexisting hyperglycemia in established diabetes remain to be explored, which could directly validate the effect of gene excision on treating diabetes. Here, we report that acute and temporally controlled excision of the Men1 gene, which encodes menin, ameliorated preexisting hyperglycemia in streptozotocin-treated mice. Moreover, Me

SUBMITTER: Yang Y 

PROVIDER: S-EPMC2996686 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature