Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study.

ABSTRACT:

Objective

To study white matter (WM) development in youth at high familial risk for bipolar disorder (BD). WM alterations are reported in youth and adults with BD. WM undergoes important maturational changes in adolescence. Age-related changes in WM microstructure using diffusion tensor imaging with tract-based spatial statistics in healthy offspring having a parent with BD were compared with those in healthy controls.

Method

A total of 45 offspring participated, including 20 healthy offspring with a parent diagnosed with BD (HBO) and 25 healthy control offspring of healthy parents (CONT). All were free of medical and psychiatric disorders. Mean fractional anisotropy (FA), radial diffusivity (RD), and longitudinal diffusivity were examined using whole-brain analyses, co-vary

SUBMITTER: Versace A 

PROVIDER: S-EPMC2996850 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature