Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach.

ABSTRACT:

Background

Carbonic anhydrases (CAs) are a family of enzymes that regulate pH homeostasis in various tissues. CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated in several other physiological and pathological processes. Functions suggested for CA IX include roles in cell adhesion and malignant cell invasion. In addition, CA IX likely regulates cell proliferation and differentiation, which was demonstrated in Car9-/- mice. These mice had gastric pit cell hyperplasia and depletion of chief cells; however, the specific molecular mechanisms behind the observed phenotypes remain unknown. Therefore, we wanted to study the effect of CA IX deficiency on whole-genome gene expression in gastric mucosa. This was done using Illumi

SUBMITTER: Kallio H 

PROVIDER: S-EPMC2996928 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature