A new analysis tool for individual-level allele frequency for genomic studies.

ABSTRACT:

Background

Allele frequency is one of the most important population indices and has been broadly applied to genetic/genomic studies. Estimation of allele frequency using genotypes is convenient but may lose data information and be sensitive to genotyping errors.

Results

This study utilizes a unified intensity-measuring approach to estimating individual-level allele frequencies for 1,104 and 1,270 samples genotyped with the single-nucleotide-polymorphism arrays of the Affymetrix Human Mapping 100K and 500K Sets, respectively. Allele frequencies of all samples are estimated and adjusted by coefficients of preferential amplification/hybridization (CPA), and large ethnicity-specific and cross-ethnicity databases of CPA and allele frequency are established. The results show that

SUBMITTER: Yang HC 

PROVIDER: S-EPMC2996943 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature