Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.

ABSTRACT:

Background

Inappropriate activation of AKT signaling is a relatively common occurrence in human tumors, and can be caused by activation of components of, or by loss or decreased activity of inhibitors of, this signaling pathway. A novel, pan AKT kinase inhibitor, GSK690693, was developed in order to interfere with the inappropriate AKT signaling seen in these human malignancies. Causal network modeling is a systematic computational analysis that identifies upstream changes in gene regulation that can serve as explanations for observed changes in gene expression. In this study, causal network modeling is employed to elucidate mechanisms of action of GSK690693 that contribute to its observed biological effects. The mechanism of action of GSK690693 was evaluated in multiple human tumo

SUBMITTER: Kumar R 

PROVIDER: S-EPMC2996947 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature