Genomic analysis of expressed sequence tags in American black bear Ursus americanus.

ABSTRACT:

Background

Species of the bear family (Ursidae) are important organisms for research in molecular evolution, comparative physiology and conservation biology, but relatively little genetic sequence information is available for this group. Here we report the development and analyses of the first large scale Expressed Sequence Tag (EST) resource for the American black bear (Ursus americanus).

Results

Comprehensive analyses of molecular functions, alternative splicing, and tissue-specific expression of 38,757 black bear EST sequences were conducted using the dog genome as a reference. We identified 18 genes, involved in functions such as lipid catabolism, cell cycle, and vesicle-mediated transport, that are showing rapid evolution in the bear lineage Three genes, Phospholamban (

SUBMITTER: Zhao S 

PROVIDER: S-EPMC2996962 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature