Bioinformatic analysis of Entamoeba histolytica SINE1 elements.

ABSTRACT:

Background

Invasive amoebiasis, caused by infection with the human parasite Entamoeba histolytica remains a major cause of morbidity and mortality in some less-developed countries. Genetically E. histolytica exhibits a number of unusual features including having approximately 20% of its genome comprised of repetitive elements. These include a number of families of SINEs - non-autonomous elements which can, however, move with the help of partner LINEs. In many eukaryotes SINE mobility has had a profound effect on gene expression; in this study we concentrated on one such element - EhSINE1, looking in particular for evidence of recent transposition.

Results

EhSINE1s were detected in the newly reassembled E. histolytica genome by searching with a Hidden Markov Model developed t

SUBMITTER: Huntley DM 

PROVIDER: S-EPMC2996970 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature