Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method.

ABSTRACT:

Background

The importance of in silico predictions for understanding cellular processes is now widely accepted, and a variety of algorithms useful for studying different biological features have been designed. In particular, the prediction of cis regulatory modules in non-coding human genome regions represents a major challenge for understanding gene regulation in several diseases. Recently, studies of the Wnt signaling pathway revealed a connection with neurodegenerative diseases such as Alzheimer's. In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/beta-catenin pathway target genes potentially involved in brain diseases.

Results

In this study, we propose 89 new W

SUBMITTER: Hodar C 

PROVIDER: S-EPMC2996972 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature