Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar.

ABSTRACT:

Background

The Atlantic salmon (Salmo salar) immunoglobulin heavy chain (IgH) locus possesses two parallel IgH isoloci (IGH-A and IGH-B), that are related to the genomic duplication event in the family Salmonidae. These duplicated IgH loci in Atlantic salmon provide a unique opportunity to examine the mechanisms of genome diversity and genome evolution of the IgH loci in vertebrates. In this study, we defined the structure of these loci in Atlantic salmon, and sequenced 24 bacterial artificial chromosome (BAC) clones that were assembled into the IGH-A (1.1 Mb) and IGH-B (0.9 Mb) loci. In addition, over 7,000 cDNA clones from the IgH variable (VH) region have been sequenced and analyzed.

Results

The present study shows that the genomic organization of the duplicated IgH loci

SUBMITTER: Yasuike M 

PROVIDER: S-EPMC2996982 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature