Gene signatures in wound tissue as evidenced by molecular profiling in the chick embryo model.

ABSTRACT:

Background

Modern functional genomic approaches may help to better understand the molecular events involved in tissue morphogenesis and to identify molecular signatures and pathways. We have recently applied transcriptomic profiling to evidence molecular signatures in the development of the normal chicken chorioallantoic membrane (CAM) and in tumor engrafted on the CAM. We have now extended our studies by performing a transcriptome analysis in the "wound model" of the chicken CAM, which is another relevant model of tissue morphogenesis.

Results

To induce granulation tissue (GT) formation, we performed wounding of the chicken CAM and compared gene expression to normal CAM at the same stage of development. Matched control samples from the same individual were used. We observed

SUBMITTER: Soulet F 

PROVIDER: S-EPMC2996991 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature