Hif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist.

ABSTRACT:

Background

Congenital heart defect (CHD) account for 25% of all human congenital abnormalities. However, very few CHD-causing genes have been identified so far. A promising approach for the identification of essential cardiac regulators whose mutations may be linked to human CHD, is the molecular and genetic analysis of heart development. With the use of a triple retinoic acid competitive antagonist (BMS189453) we previously developed a mouse model of congenital heart defects (81%), thymic abnormalities (98%) and neural tube defects (20%). D-TGA (D-transposition of great arteries) was the most prevalent cardiac defect observed (61%). Recently we were able to partially rescue this abnormal phenotype (CHD were reduced to 64.8%, p = 0.05), by oral administration of folic acid (FA). No

SUBMITTER: Amati F 

PROVIDER: S-EPMC2996993 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature