Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis.

ABSTRACT:

Background

The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis.

Methods

In the discovery study, the Rotterdam Study-I, 7 single nucleotide polymorphisms (SNPs) were genotyped and tested for association with hip (284 cases, 2772 controls), knee (665 cases, 2075 controls), and hand OA (874 cases, 2184 controls) using an additive model. In the replication stage one SNP (rs1256031) was tested in an additional 2080 hip, 1318 knee and 557 hand OA cases and 4001, 2631 and 1699 controls respectively. Fixed- and random-effects meta-analyses were performed over the complete dataset including 2364 hip, 1983 knee and 1431 hand OA cases and approximately 6000 controls.

Results

The C allele of rs1256031 wa

SUBMITTER: Kerkhof HJ 

PROVIDER: S-EPMC2997092 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature