Impaired error-likelihood prediction in medial prefrontal cortex in schizophrenia.

ABSTRACT: The cognitive impairment in individuals with schizophrenia includes deficits of working memory in dorsolateral prefrontal cortex and deficits of performance monitoring in medial prefrontal cortex (MPFC). Recent work suggests a more general role for MPFC in predicting the outcome of actions and then evaluating those predictions. Here we investigate, in individuals with schizophrenia, two specific effects associated with this role: the error likelihood effect (occurring on trials with correct performance, but features that predict a high probability of errors), and the error unexpectedness effect (occurring on trials with an error, but features that predict errors are of low probability). In a rapid event-related fMRI design with a modified version of the change-signal task, a cue incidental

SUBMITTER: Krawitz A 

PROVIDER: S-EPMC2997134 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature