TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.

ABSTRACT:

Background & aims

Gastric stem cells are located in the isthmus of the gastric glands and give rise to epithelial progenitors that undergo bipolar migration and differentiation into pit and oxyntic lineages. Although gastric mucus neck cells located below the isthmus express trefoil factor family 2 (TFF2) protein, TFF2 messenger RNA transcripts are concentrated in cells above the neck region in normal corpus mucosa, suggesting that TFF2 transcription is a marker of gastric progenitor cells.

Methods

Using a BAC strategy, we generated a transgenic mouse with a tamoxifen-inducible Cre under the control of the TFF2 promoter (TFF2-BAC-Cre(ERT2)) and analyzed the lineage derivation from TFF2 mRNA transcript-expressing (TTE) cells.

Results

TTE cells were localized to the ist

SUBMITTER: Quante M 

PROVIDER: S-EPMC2997174 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature