Identification of evolutionarily conserved genetic regulators of cellular aging.

ABSTRACT: To identify new genetic regulators of cellular aging and senescence, we performed genome-wide comparative RNA profiling with selected human cellular model systems, reflecting replicative senescence, stress-induced premature senescence, and distinct other forms of cellular aging. Gene expression profiles were measured, analyzed, and entered into a newly generated database referred to as the GiSAO database. Bioinformatic analysis revealed a set of new candidate genes, conserved across the majority of the cellular aging models, which were so far not associated with cellular aging, and highlighted several new pathways that potentially play a role in cellular aging. Several candidate genes obtained through this analysis have been confirmed by functional experiments, thereby validating the exper

SUBMITTER: Laschober GT 

PROVIDER: S-EPMC2997327 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature