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Imaging-genetics applications in child psychiatry.


ABSTRACT:

Objective

To place imaging-genetics research in the context of child psychiatry.

Method

A conceptual overview is provided, followed by discussion of specific research examples.

Results

Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.

Conclusions

Child psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.

SUBMITTER: Pine DS 

PROVIDER: S-EPMC2997350 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Publications

Imaging-genetics applications in child psychiatry.

Pine Daniel S DS   Ernst Monique M   Leibenluft Ellen E  

Journal of the American Academy of Child and Adolescent Psychiatry 20100409 8


<h4>Objective</h4>To place imaging-genetics research in the context of child psychiatry.<h4>Method</h4>A conceptual overview is provided, followed by discussion of specific research examples.<h4>Results</h4>Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.<h4>Conclusions</h4>Child psychiatry applications of imaging ge  ...[more]

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