Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides.

ABSTRACT: Oligoarginine and guanidinium-rich molecular transporters have been shown to facilitate the intracellular delivery of a diverse range of biologically relevant cargos. Several such transporters have been suggested to interact with cell-surface heparan sulfate proteoglycans as part of their cell-entry pathway. Unlike for other guanidinium-rich transporters, the cellular uptake of guanidinoglycosides at nanomolar concentrations is exclusively heparan sulfate dependent. As distinct cells differ in their expression levels and/or the composition of cell-surface heparan sulfate proteoglycans, one might be able to exploit such differences to selectively target certain cell types. To systematically investigate the nature of their cell-surface interactions, monomeric and dimeric guanidinoglycosides

SUBMITTER: Dix AV 

PROVIDER: S-EPMC2997625 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature