MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling.

ABSTRACT:

Rationale

Establishment of a functional vasculature requires the interconnection and remodeling of nascent blood vessels. Precise regulation of factors that influence endothelial cell migration and function is essential for these stereotypical vascular patterning events. The secreted Slit ligands and their Robo receptors constitute a critical signaling pathway controlling the directed migration of both neurons and vascular endothelial cells during embryonic development, but the mechanisms of their regulation are incompletely understood.

Objective

To identify microRNAs regulating aspects of the Slit-Robo pathway and vascular patterning.

Methods and results

Here, we provide evidence that microRNA (miR)-218, which is encoded by an intron of the Slit genes, inhibits the e

SUBMITTER: Small EM 

PROVIDER: S-EPMC2997642 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature