Genomic aberrations in lung adenocarcinoma in never smokers.

ABSTRACT:

Background

Lung cancer in never smokers would rank as the seventh most common cause of cancer death worldwide.

Methods and findings

We performed high-resolution array comparative genomic hybridization analysis of lung adenocarcinoma in sixty never smokers and identified fourteen new minimal common regions (MCR) of gain or loss, of which five contained a single gene (MOCS2, NSUN3, KHDRBS2, SNTG1 and ST18). One larger MCR of gain contained NSD1. One focal amplification and nine gains contained FUS. NSD1 and FUS are oncogenes hitherto not known to be associated with lung cancer. FISH showed that the amplicon containing FUS was joined to the next telomeric amplicon at 16p11.2. FUS was over-expressed in 10 tumors with gain of 16p11.2 compared to 30 tumors without that gain. Other

SUBMITTER: Job B 

PROVIDER: S-EPMC2997777 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature