Long range interactions regulate Igf2 gene transcription during skeletal muscle differentiation.

ABSTRACT: The differentiation, maintenance, and repair of skeletal muscle is controlled by interactions between genetically determined transcriptional programs regulated by myogenic transcription factors and environmental cues activated by growth factors and hormones. Signaling through the insulin-like growth factor 1 (IGF1) receptor by locally produced IGF2 defines one such pathway that is critical for normal muscle growth and for regeneration after injury. IGF2 gene and protein expression are induced as early events in muscle differentiation, but the responsible molecular mechanisms are unknown. Here we characterize a distal DNA element within the imprinted mouse Igf2-H19 locus with properties of a muscle transcriptional enhancer. We find that this region undergoes a transition to open chromatin d

SUBMITTER: Alzhanov DT 

PROVIDER: S-EPMC2998108 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature