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Steroid receptor coactivator (SRC) family: masters of systems biology.

ABSTRACT: The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Since their discovery ∼15 years ago, the extraordinary sum of examination of SRC function has shaped the foundation of our knowledge for the now 350+ coregulators that have been identified to date. In this perspective, we retrace our steps into the field of coregulators and provide a summary of selected seminal work that helped define the SRCs as masters of systems biology.

SUBMITTER: York B 

PROVIDER: S-EPMC2998129 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Steroid receptor coactivator (SRC) family: masters of systems biology.

York Brian B   O'Malley Bert W BW  

The Journal of biological chemistry 20101018 50

The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Since their discovery ∼15 years ago, the extraordinary sum of examination of SRC function has shaped the foundation of our knowledge for the now 350+ coregulators that have been identified to date. In this perspective, we retrace our steps into the field of coregulators and  ...[more]

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