Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase.

ABSTRACT: F1-ATPase is the catalytic component of the ATP synthase molecular machine responsible for most of the uphill synthesis of ATP in living systems. The enormous advances in biochemical and structural studies of this machine provide an opportunity for detailed understanding of the nature of its rotary mechanism. However, further quantitative progress in this direction requires development of reliable ways of translating the observed structural changes to the corresponding energies. This requirement is particularly challenging because we are dealing with a large system that couples major structural changes with a chemical process. The present work provides such a structure-function correlation by using the linear response approximation to describe the rotary mechanism. This approach allows one

SUBMITTER: Strajbl M 

PROVIDER: S-EPMC299816 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature