Proteomic analysis of streptomycin resistant and sensitive clinical isolates of Mycobacterium tuberculosis.

ABSTRACT:

Background

Streptomycin (SM) is a broad spectrum antibiotic and is an important component of any anti-tuberculosis therapy regimen. Several mechanisms have been proposed to explain the emergence of resistance but still our knowledge is inadequate. Proteins form a very complex network and drugs are countered by their modification/efflux or over expression/modification of targets. As proteins manifest most of the biological processes, these are attractive targets for developing drugs, immunodiagnostics or therapeutics. The aim of present study was to analyze and compare the protein profile of whole cell extracts from Mycobacterium tuberculosis clinical isolates susceptible and resistant to SM.

Results

Two-dimensional gel electrophoresis (2DE) and matrix-assisted laser desorpti

SUBMITTER: Sharma P 

PROVIDER: S-EPMC2998474 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature