Dataset Information
Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1).
Ontology highlight
ABSTRACT: Background
Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, β- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37 °C in the presence of 5% CO₂) using MDCK cell lines.Result
Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples, followed by β- lactoglobulin. α-Lactalbumin had less antiviral activity even after esterification.Conclusion
Esterification of whey proteins fractions especially lactoferrin and β-lactoglobulin enhanced their antiviral activity against H5N1 in a concentration dependent manner.
SUBMITTER: Taha SH
PROVIDER: S-EPMC2998487 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1).
Virology journal 20101119
<h4>Background</h4>Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, β- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37 °C in the presence of 5% CO₂) using MDCK cell lines.<h4>Result</h4>Both the native and esterified lactofer ...[more]
