Effectiveness of esterified whey proteins fractions against Egyptian Lethal Avian Influenza A (H5N1).

ABSTRACT:

Background

Avian influenza A (H5N1) virus is one of the most important public health concerns worldwide. The antiviral activity of native and esterified whey proteins fractions (α- lactalbumin, β- lactoglobulin, and lactoferrin) was evaluated against A/chicken/Egypt/086Q-NLQP/2008 HPAI (H5N1) strain of clade 2.2.1 (for multiplicity of infection (1 MOI) after 72 h of incubation at 37 °C in the presence of 5% CO₂) using MDCK cell lines.

Result

Both the native and esterified lactoferrin seem to be the most active antiviral protein among the tested samples, followed by β- lactoglobulin. α-Lactalbumin had less antiviral activity even after esterification.

Conclusion

Esterification of whey proteins fractions especially lactoferrin and β-lactoglobulin enhanced their antivira

SUBMITTER: Taha SH 

PROVIDER: S-EPMC2998487 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature