Protein complex forming ability is favored over the features of interacting partners in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks.

ABSTRACT:

Background

Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level. A recent study revealed the importance of the features of the interacting protein partners, viz., the coefficient of functionality and clustering coefficient in controlling the protein evolutionary rates in a protein-protein interaction (PPI) network.

Results

By multivariate regression analysis we found that the three parameters: probability of complex formation, expression level and degree of a protein independently guide the evolutionary rates of proteins in the PPI network. The contribution of the complex forming property of a protein and its expression level led to nearly 43% of the total variation as observed from

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC2998497 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature