Three novel NEIL1 promoter polymorphisms in gastric cancer patients.

ABSTRACT:

Aim

To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.

Methods

The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.

Results

Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.

Conclusion

Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

SUBMITTER: Goto M 

PROVIDER: S-EPMC2999164 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature