Robust inference of the context specific structure and temporal dynamics of gene regulatory network.

ABSTRACT:

Background

Response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions, or regulatory networks. To lead to appropriate responses, regulatory network should be 1) context-specific, i.e., its constituents and topology depend on the phonotypical and experimental context including tissue types and cell conditions, such as damage, stress, macroenvironments of cell, etc. and 2) time varying, i.e., network elements and their regulatory roles change actively over time to control the endogenous cell states e.g. different stages in a cell cycle.

Results

A novel network model PathRNet and a reconstruction approach PATTERN are proposed for reconstructing the context specific time varying regulatory networks by integrating microarray g

SUBMITTER: Meng J 

PROVIDER: S-EPMC2999341 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature