Core genome components and lineage specific expansions in malaria parasites plasmodium.

ABSTRACT:

Background

The increasing resistance of Plasmodium, the malaria parasites, to multiple commonly used drugs has underscored the urgent need to develop effective antimalarial drugs and vaccines. The new direction of genomics-driven target discovery has become possible with the completion of parasite genome sequencing, which can lead us to a better understanding of how the parasites develop the genetic variability that is associated with their response to environmental challenges and other adaptive phenotypes.

Results

We present the results of a comprehensive analysis of the genomes of six Plasmodium species, including two species that infect humans, one that infects monkeys, and three that infect rodents. The core genome shared by all six species is composed of 3,351 genes, wh

SUBMITTER: Cai H 

PROVIDER: S-EPMC2999343 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature