Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.

ABSTRACT: The success of high resolution genetic mapping of disease predisposition and quantitative trait loci in humans and experimental animals depends on the positions of key crossover events around the gene of interest. In mammals, the majority of recombination occurs at highly delimited 1-2 kb long sites known as recombination hotspots, whose locations and activities are distributed unevenly along the chromosomes and are tightly regulated in a sex specific manner. The factors determining the location of hotspots started to emerge with the finding of PRDM9 as a major hotspot regulator in mammals, however, additional factors modulating hotspot activity and sex specificity are yet to be defined. To address this limitation, we have collected and mapped the locations of 4829 crossover events occurri

SUBMITTER: Billings T 

PROVIDER: S-EPMC2999565 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature