Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15.

ABSTRACT:

Background

Little is known about whether associations between childhood adiposity and later adverse cardiovascular health outcomes are driven by tracking of overweight from childhood to adulthood and/or by vascular and metabolic changes from childhood overweight that persist into adulthood. Our objective is to characterise associations between trajectories of adiposity across childhood and a wide range of cardiovascular risk factors measured in adolescence, and explore the extent to which these are mediated by fat mass at age 15.

Methods and findings

Using data from the Avon Longitudinal Study of Parents and Children, we estimated individual trajectories of ponderal index (PI) from 0-2 years and BMI from 2-10 years using random-effects linear spline models (N = 4601). We exp

SUBMITTER: Howe LD 

PROVIDER: S-EPMC2999567 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature