Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma.

ABSTRACT:

Background

Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in particular those with active liver disease and cirrhosis.

Methods

We catalogued all published interactions between HBV and human proteins, identifying 250 descriptions of HBV and human protein interactions and 146 unique human proteins that interact with HBV proteins by text mining.

Results

Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HBV are made up of core proteins that are interconnected with many pathways. A global analysis based on functional annotation highlighted the enrichme

SUBMITTER: Wu ZJ 

PROVIDER: S-EPMC2999591 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature