Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

ABSTRACT:

Aim

To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.

Methods

Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.

Results

There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or

SUBMITTER: Yang MD 

PROVIDER: S-EPMC2999679 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature