Indian Hedgehog and its targets in human endometrium: menstrual cycle expression and response to CDB-2914.

ABSTRACT:

Context

Progesterone is critical for secretory endometrial differentiation in women, but its downstream mediators are poorly understood.

Objective

Our objective was to investigate endometrial expression of Indian Hedgehog (IHH) and genes involved in its signaling [smoothened (SMO), patched-1 (PTCH1), glioma-associated oncogene homolog 1 (GLI1), and GLI2] during the menstrual cycle and the effects of the selective progesterone receptor modulator CDB-2914 on its expression.

Design and setting

Comparisons between normally cycling volunteers and women with symptomatic fibroids who received CDB-2914 or placebo were made at a clinical research center.

Patients and interventions

Endometrial biopsy was performed on 34 volunteers, 17 additional women with fibroids.

M

SUBMITTER: Wei Q 

PROVIDER: S-EPMC2999967 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature